| ncRNA name | CXCR4 siRNA |
| ncRNA Category | siRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | human UM cell line OCM3 |
| Methods | siRNA transfection, qRT-PCR, transwell assay, histopathologic analysis |
| Expression pattern | associated |
| Functional description | Blocking CXCR4 gene expression by transfection with CXCR4 siRNA inhibited both the chemotactic and the invasive properties of uveal melanoma cells exposed to factors produced by human livers. Uveal melanoma cells transfected with CXCR4 siRNA produced fewer liver metastases than untreated uveal melanoma cells or uveal melanoma cells transfected with control siRNA. |
| PubMed ID | 19553629 |
| Year | 2009 |
| Title | Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases. |
| Drug-related ncRNA | NO |
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